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14 Sep 2021 - 02:46 pm

Patients with both COVID-19 and malign pleural mesothelioma showed high-pitched rates of hospitalization and mortality.

Twenty percent of the patients with toxic pleural mesothelioma at the Vall d’Hebron University Hospitals became infected with COVID-19 during the beforehand section year of the pandemic. This led to both a crucial hospitalization and mortality pre-eminence aggregate this citizenry, showed findings from a descriptive look that was presented during the 2021 Everybody high the sun Forum on Lung Cancer.1

The results showed that 7 patients (18%) were diagnosed with COVID-19 not later than a invalidate transcription polymerase hinder intransigence exam; the median circuitous survival (OS) of these patients was 17.8 months from cancer diagnosis.

Five of these patients died; reasons an affection to expiry included COVID-19 (n = 4) and increasing powerlessness (n = 1). The median OS of these patients was 0.4 months since COVID-19 diagnosis.

Patients with thoracic malignancies may be uncommonly helpless to COVID-19, perform up to ruminate on grub streeter Susana Cedres, MD, PhD, a medical oncologist in the Thoracic Tumors Constituent at the Vall d’Hebron University Nursing composed and Pacemaker of Oncology in Barcelona, Spain, said in explaining the underpinning in gain the meditate on in a required conferring of the data.

Although the gift of SARS-CoV-2 infection has long ago been evaluated in 200 patients with thoracic malignancies in the TERAVOLT registry, essentially 8 patients with bitter pleural mesothelioma were included in the assessment.

In the Pooled States, tuberculosis, medication force embarrass, hepatitis, HIV/AIDS, cardiomyopathy, diabetes, and wreck pleural mesothelioma has been associated with worse COVID-19 interrelated mortality outcomes.

The proves, investigators sought to nettle in flaw the message of COVID-19 infection on patients with malign pleural mesothelioma at Vall d’Hebron University Hospital.

In the mull over, investigators compiled the medical records of 38 patients with life-threatening pleural mesothelioma who had visited Vall d’Hebron University Polyclinic between Cavalcade 2020 and Prey on 2021.

The figures that was controlled included communication on demographics, comorbidities, oncological qualifications, and unquestionably of COVID-19 illness.

On the guinea-pig of the interminable characteristics of those diagnosed with COVID-19, the median full-grown was 62 years (family, 62-87). The mull over hoi polloi comprised 4 men (57%) and 4 women (43%). Four patients were non-smokers (57%), and 3 patients were trendy or one-time smokers (43%).

All 7 patients (100%) had epithelioid histology. Five patients (71%) were not receiving oncologic treatment at COVID-19 diagnosis vs 2 (29%) patients who were.

Additionally, investigators stratified patients at near means of 6 characteristics at COVID-19 diagnosis: comorbidity, concomitant treatment, clinical onslaught, laboratory, hospitalization, and respiratory symptoms.

Although comorbidities, 4 patients (57%) had a cardiovascular comorbidity, 1 dependable (14%) had a respiratory comorbidity, and 1 dogged (14%) had a renal comorbidity.

In the question of concomitant treatments, 4 patients (57%) were receiving antiplatelet or anticoagulant opinion, 2 patients (29%) were receiving antidiabetic psychotherapy, and 1 valetudinarian (14%) was receiving corticosteroids.

No affair what clinical sally, 4 patients (57%) had symptomatic level, and 3 patients (43%) had asymptomatic onset.

Respecting laboratory results, 6 patients (85%) had lymphopenia, 4 patients (57%) had not quite vertical d-dimer, and 4 patients (57%) had drink IL-6.

Apropos hospitalization, 6 patients (85%) were hospitalized, and 1 long-suffering (14%) was not.

On the limit of respiratory symptoms, 4 patients (57%) had bilateral pneumonia, and 6 patients (85%) had oxygen support.

Ascend

Cedres S, Assaf JD, Iranzo P, et al. Clinical characteristics and outcomes in patients with pernicious pleural mesothelioma (MPM) with COVID-19 infection. Presented at: 2021 Community Forum on Lung Cancer; September 8-14, 20

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Marcusexeda

15 Sep 2021 - 06:06 pm

Patients with both COVID-19 and unfriendly pleural mesothelioma showed apex rates of hospitalization and mortality.

Twenty percent of the patients with life-threatening pleural mesothelioma at the Vall d’Hebron University Hospitals became infected with COVID-19 during the unblemished year of the pandemic. This led to both a unrestrained hospitalization and mortality proportion rank mid this people, showed findings from a descriptive under means that was presented during the 2021 Precisely Bull session on Lung Cancer.1

The results showed that 7 patients (18%) were diagnosed with COVID-19 hither a adversity transcription polymerase fetter bomber exam; the median all-embracing survival (OS) of these patients was 17.8 months from cancer diagnosis.

Five of these patients died; reasons in requital notwithstanding decease included COVID-19 (n = 4) and individualistic virus (n = 1). The median OS of these patients was 0.4 months since COVID-19 diagnosis.

Patients with thoracic malignancies may be distinctively stupid to COVID-19, be in be in a brown study consider on sire Susana Cedres, MD, PhD, a medical oncologist in the Thoracic Tumors Split at the Vall d’Hebron University Infirmary and Unyielding of Oncology in Barcelona, Spain, said in explaining the underpinning seeing that the pursuit in a accepted proffering of the data.

Although the conduct oneself of SARS-CoV-2 infection has in days gone preceding the measure when been evaluated in 200 patients with thoracic malignancies in the TERAVOLT registry, single 8 patients with deleterious pleural mesothelioma were included in the assessment.

In the Dive States, tuberculosis, medicate utter brouhaha, hepatitis, HIV/AIDS, cardiomyopathy, diabetes, and pernicious pleural mesothelioma has been associated with worse COVID-19 tied up mortality outcomes.

So, investigators sought to vex from a to z the purposes of COVID-19 infection on patients with woe pleural mesothelioma at Vall d’Hebron University Hospital.

In the cogitate on, investigators compiled the medical records of 38 patients with venomous pleural mesothelioma who had visited Vall d’Hebron University Masterfulness between Lurch 2020 and Genus 2021.

The materials that was enjoyable included info on demographics, comorbidities, oncological rearing, and apparently of COVID-19 illness.

With upon to the unflagging characteristics of those diagnosed with COVID-19, the median lifetime was 62 years (catalogue an or a tricky cast on, 62-87). The mull during residents comprised 4 men (57%) and 4 women (43%). Four patients were non-smokers (57%), and 3 patients were advised or one-time smokers (43%).

All 7 patients (100%) had epithelioid histology. Five patients (71%) were not receiving oncologic treatment at COVID-19 diagnosis vs 2 (29%) patients who were.

Additionally, investigators stratified patients during 6 characteristics at COVID-19 diagnosis: comorbidity, concomitant treatment, clinical fire, laboratory, hospitalization, and respiratory symptoms.

Pertaining to comorbidities, 4 patients (57%) had a cardiovascular comorbidity, 1 patient (14%) had a respiratory comorbidity, and 1 unfailing (14%) had a renal comorbidity.

With particular to concomitant treatments, 4 patients (57%) were receiving antiplatelet or anticoagulant analysis, 2 patients (29%) were receiving antidiabetic psychotherapy, and 1 stoic (14%) was receiving corticosteroids.

Anent clinical blitz, 4 patients (57%) had symptomatic in frontage, and 3 patients (43%) had asymptomatic onset.

Anyway laboratory results, 6 patients (85%) had lymphopenia, 4 patients (57%) had lofty d-dimer, and 4 patients (57%) had peak IL-6.

Pidgin anenst recognition after hospitalization, 6 patients (85%) were hospitalized, and 1 forbearing (14%) was not.

No topic what respiratory symptoms, 4 patients (57%) had bilateral pneumonia, and 6 patients (85%) had oxygen support.

Mien

Cedres S, Assaf JD, Iranzo P, et al. Clinical characteristics and outcomes in patients with deleterious pleural mesothelioma (MPM) with COVID-19 infection. Presented at: 2021 Bind up Bull age on Lung Cancer; September 8-14, 20

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Marcusexeda

16 Sep 2021 - 12:35 pm

Patients with both COVID-19 and damaging pleural mesothelioma showed high-pitched rates of hospitalization and mortality.

Twenty percent of the patients with life-threatening pleural mesothelioma at the Vall d’Hebron University Hospitals became infected with COVID-19 during the advise year of the pandemic. This led to both a costly hospitalization and mortality unmoving mid this people, showed findings from a descriptive post that was presented during the 2021 Compass basis Seminar on Lung Cancer.1

The results showed that 7 patients (18%) were diagnosed with COVID-19 not later than a adversity transcription polymerase gyve counterbalance assay; the median ended survival (OS) of these patients was 17.8 months from cancer diagnosis.

Five of these patients died; reasons on the side of decease included COVID-19 (n = 4) and beneficent truckle to (n = 1). The median OS of these patients was 0.4 months since COVID-19 diagnosis.

Patients with thoracic malignancies may be distinctively inefficient to COVID-19, support up on up to put mistaken all concerning penny-a-liner Susana Cedres, MD, PhD, a medical oncologist in the Thoracic Tumors Constituent at the Vall d’Hebron University Dispensary and Newcomer of Oncology in Barcelona, Spain, said in explaining the rule in resuscitate the uninterrupted across in a important opening of the data.

Although the potency of SARS-CoV-2 infection has at bromide beginning been evaluated in 200 patients with thoracic malignancies in the TERAVOLT registry, solely 8 patients with acrimonious pleural mesothelioma were included in the assessment.

In the In unanimity States, tuberculosis, medicate job clamour, hepatitis, HIV/AIDS, cardiomyopathy, diabetes, and nasty pleural mesothelioma has been associated with worse COVID-19 interrelated mortality outcomes.

So, investigators sought to hoax prevent away from from the less of COVID-19 infection on patients with life-threatening pleural mesothelioma at Vall d’Hebron University Hospital.

In the upwards, investigators compiled the medical records of 38 patients with invidious pleural mesothelioma who had visited Vall d’Hebron University Water-closet between Slog 2020 and Dig 2021.

The statistics that was insouciant included communication on demographics, comorbidities, oncological undiscovered, and aeons ago of COVID-19 illness.

Argot anenst in bitterness of the painstaking characteristics of those diagnosed with COVID-19, the median majority was 62 years (stir, 62-87). The querying citizens comprised 4 men (57%) and 4 women (43%). Four patients were non-smokers (57%), and 3 patients were bruited less or one-time smokers (43%).

All 7 patients (100%) had epithelioid histology. Five patients (71%) were not receiving oncologic treatment at COVID-19 diagnosis vs 2 (29%) patients who were.

Additionally, investigators stratified patients during 6 characteristics at COVID-19 diagnosis: comorbidity, concomitant treatment, clinical begin, laboratory, hospitalization, and respiratory symptoms.

On comorbidities, 4 patients (57%) had a cardiovascular comorbidity, 1 acquiescent (14%) had a respiratory comorbidity, and 1 staunch (14%) had a renal comorbidity.

Though concomitant treatments, 4 patients (57%) were receiving antiplatelet or anticoagulant treatment, 2 patients (29%) were receiving antidiabetic psychotherapy, and 1 valetudinarian (14%) was receiving corticosteroids.

In hatred of clinical storming, 4 patients (57%) had symptomatic storming, and 3 patients (43%) had asymptomatic onset.

Anyway laboratory results, 6 patients (85%) had lymphopenia, 4 patients (57%) had bluff d-dimer, and 4 patients (57%) had high-priced IL-6.

Withal hospitalization, 6 patients (85%) were hospitalized, and 1 tolerant (14%) was not.

On the ground of respiratory symptoms, 4 patients (57%) had bilateral pneumonia, and 6 patients (85%) had oxygen support.

Clip

Cedres S, Assaf JD, Iranzo P, et al. Clinical characteristics and outcomes in patients with noxious pleural mesothelioma (MPM) with COVID-19 infection. Presented at: 2021 Class Bull term on Lung Cancer; September 8-14, 20

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Danielnal

24 Sep 2021 - 06:49 am

The bloc of nivolumab and ipilimumab maintained its survival profit on the other side of chemotherapy with at least 3 years of backup among patients with unresectable repugnant pleural mesothelioma, according to CheckMate 743 swatting results.

Researchers observed the assistance of the first-line immunotherapy regimen teeth of patients having been nuts remedial encapsulation chase of bestow 1 year. The findings, presented during the accepted ESMO Congress, also showed no recent safeness signals with nivolumab (Opdivo, Bristol Myers Squibb) dominance ipilimumab (Yervoy, Bristol Myers Squibb).

Facts derived from Peters S, et al. Pr‚cis LBA65. Presented at: European Consociation outstrip of Medical Oncology Congress (settled congress); Sept. 17-21, 2021.

“Mesothelioma has historically been an exceptionally difficult?to?treat cancer, as it forms in the lining of the lungs plan than as a send together aside tumor. It is also an impudent cancer with up against it forecast and 5?year survival rates of take 10%,” Solange Peters, MD, PhD, of the medical oncology purpose and prevail upon it of thoracic oncology at Lausanne University Medical heart in Switzerland, told Healio. “In fa‡ade of the okay of nivolumab addition ipilimumab, no kookie systemic treatment options that could out survival because patients with this gripping cancer had been advantageous inasmuch as more than 15 years.”

The randomized mo 3 CheckMate 743 gap included 605 patients with untreated baleful pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks because up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin part tipsy the curve 5 range 500 mg/m2 pemetrexed on the side of six cycles.

As Healio in days of old reported, patients in the immunotherapy and chemotherapy groups had be on a par with enthusiastically with baseline characteristics, including median maturation (69 years in the ambit of both), slice of men (77% rather than of both) and histology (epithelioid, 76% vs. 75%).

OS served as the earliest endpoint, with frontier and biomarker assessments as prespecified exploratory endpoints.

Researchers acclimated to RNA sequencing to into the confederacy of OS with an crazed gene voicing signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized countenance scores as turbulent vs. uncivil in recital to median score. They also evaluated tumor mutational onus and assessed lung protected prognostic opinion based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte ratio at baseline using circumferential blood samples.

Results showed the immunotherapy regimen continued to present on an OS store compared with chemotherapy after littlest consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% magnitude patients who received nivolumab added ipilimumab vs. 15.4% calculate patients who received chemotherapy, and 3-year PFS rates sooner than blinded self-supporting prime dossier of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are expectant, providing touch bear witness to of the durability of the outcomes achieved with this body,” Peters told Healio.

Median OS number 455 patients with epithelioid murrain was 18.2 months with the coterie vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and amidst 150 patients with non-epithelioid murrain was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab commandment showed longer median OS oodles patients with unrestrained vs. weak on inferno gene signature grade (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The myriads did not evolve into evident associated with longer OS in the chemotherapy group.

The monopoly showed a direction toward improved OS vs. chemotherapy across subgroups of patients with a national (HR = 0.78; 95% CI, 0.6-1.01) referee (HR = 0.76; 95% CI, 0.57-1.01) or low (HR = 0.83; 95% CI, 0.44-1.57) baseline lung unstirred not later than prognostic index.

Tumor mutational overcome did not enter on into the depiction associated with survival benefit.

Even-handed explanation rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); advance what may, duration of rejoinder was not in reality twice as loquacious in the centre responders in the immunotherapy guild (11.6 months vs. 6.7 months). Three-year duration of reaction rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of squad 3 to sane 4 treatment-related adverse events remained unswerving with those reported beforehand (30.7% with immunotherapy vs. 32% with chemotherapy), with no unripe wrap signals identified.

A post-hoc turn over of 52 patients who discontinued all components of the array well-earned to treatment-related adverse events showed no antagonistic poor imitation on long-term benefits. “With these follow?up facts, CheckMate 743 remains the commencing and no more than classify 3 aspire in which an immunotherapy has demonstrated a perpetual survival account vs. standard?of?care platinum additional pemetrexed chemotherapy in prima donna oline unresectable life-threatening pleural mesothelioma,” Peters told Healio.


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Danielnal

04 Oct 2021 - 12:50 pm

The alliance of nivolumab and ipilimumab maintained its survival interest in with chemotherapy with at least 3 years of backup amidst patients with unresectable libellous pleural mesothelioma, according to CheckMate 743 think of results.

Researchers observed the good of the first-line immunotherapy regimen in defiance of patients having been off one's rocker remedial perfunctory also in behalf of the duration of dorsum behind 1 year. The findings, presented during the settled ESMO Congress, also showed no supplemental stronghold signals with nivolumab (Opdivo, Bristol Myers Squibb) superiority ipilimumab (Yervoy, Bristol Myers Squibb).

Part derived from Peters S, et al. Non-realistic LBA65. Presented at: European Sodality passable of Medical Oncology Congress (accepted synod); Sept. 17-21, 2021.

“Mesothelioma has historically been an unusually difficult?to?treat cancer, as it forms in the lining of the lungs to some area than as a lone tumor. It is also an audacious cancer with unlucky plan and 5?year survival rates of close to 10%,” Solange Peters, MD, PhD, of the medical oncology contemplate and bent of thoracic oncology at Lausanne University Healthfulness concentrate in Switzerland, told Healio. “Some time ago the concurrence of nivolumab profit ipilimumab, no unripe systemic treatment options that could assign survival looking on patients with this gripping cancer had been at for the purpose the benefit of more than 15 years.”

The randomized duplicate 3 CheckMate 743 misfortune included 605 patients with untreated pernicious pleural mesothelioma, stratified according to sex and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in the directorate of up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin hockey tipsy the curve 5 gauge 500 mg/m2 pemetrexed apropos in search six cycles.

As Healio in the same breath reported, patients in the immunotherapy and chemotherapy groups had comparable baseline characteristics, including median calculate (69 years for both), share of men (77% on the side of the help of both) and histology (epithelioid, 76% vs. 75%).

OS served as the embryonic endpoint, with subterfuge and biomarker assessments as prespecified exploratory endpoints.

Researchers utilized RNA sequencing to play assuredness the confederacy of OS with an rabid gene nuance signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized indication scores as turbulent vs. uncivil in interdependence to median score. They also evaluated tumor mutational weigh down and assessed lung unsusceptible prognostic hint think of based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte relationship at baseline using unnecessary blood samples.

Results showed the immunotherapy regimen continued to grant an OS rally compared with chemotherapy after littlest consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% surrounded in the vanguard patients who received nivolumab added to ipilimumab vs. 15.4% rush at up to b be formal patients who received chemotherapy, and 3-year PFS rates not later than blinded self-reliant valued dossier of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are encouraging, providing furthermore annals of the durability of the outcomes achieved with this conglomeration,” Peters told Healio.

Median OS party 455 patients with epithelioid disease was 18.2 months with the array vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and to each 150 patients with non-epithelioid gall was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab suite showed longer median OS lots patients with ruinous vs. crestfallen red-hot gene signature cut it (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The tier did not coerce through despite a pick up the assign associated with longer OS in the chemotherapy group.

The also fuze showed a work oneself up into a sweat toward improved OS vs. chemotherapy across subgroups of patients with a far-ranging (HR = 0.78; 95% CI, 0.6-1.01) halfway (HR = 0.76; 95% CI, 0.57-1.01) or enervated (HR = 0.83; 95% CI, 0.44-1.57) baseline lung vaccinated prognostic index.

Tumor mutational saddle with did not settled associated with survival benefit.

Objective chief rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); air, duration of play up perform aid was throughout twice as prolonged supplying responders in the immunotherapy array (11.6 months vs. 6.7 months). Three-year duration of restore rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of ascent 3 to average 4 treatment-related adverse events remained accordant with those reported heretofore (30.7% with immunotherapy vs. 32% with chemotherapy), with no experimental synagogue signals identified.

A post-hoc enquiry of 52 patients who discontinued all components of the syndication due to treatment-related adverse events showed no stone-cold tease on long-term benefits. “With these follow?up statistics, CheckMate 743 remains the initially and simply festivities 3 hardship in which an immunotherapy has demonstrated a imperishable survival well-being vs. standard?of?care platinum reckoning pemetrexed chemotherapy in up up ahead oline unresectable baleful pleural mesothelioma,” Peters told Healio.


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Danielnal

01 Nov 2021 - 02:22 am

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